Description
Product Characteristics:
SERPINI2 is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. It may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.
Synonyms: MEPI, Myoepithelium derived serine protease inhibitor, Pancpin, Pancreas specic protein TSA2004, Peptidase inhibitor 14, PI 14, PI14, Protease inhibitor 14, Serine or cysteine proteinase inhibitor clade I neuroserpin member 2, Serine or cysteine proteinase inhibitor clade I pancpin member 2, Serpin I2, Serpin peptidase inhibitor clade I pancpin member 2, TSA2004, SPI2_HUMAN, SERPINI2.
Target Information: The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]